Redox Chemistry and Biology of Thiols

<p>1. Basic concepts of thiol chemistry and biology<br>2. Chemical basis of cysteine reactivity: Acidity and nucleophilicity<br>3. Computational functional analysis of cysteine residues in proteins<br>4. Global approaches for protein thiol redox state detection and quantification<br>5. Thiol oxidation by biologically-relevant reactive species<br>6. Thiyl radicals: formation, properties and detection<br>7. Detection of the oxidation products of thiols: disulfides, sulfenic, sulfinic and sulfonic acids<br>8. Biochemistry and detection of S-nitrosothiols<br>9. Thiol modification and signaling by biological electrophiles<br>10. Thioredoxin and glutathione reductases<br>11. Functional plasticity in the thioredoxin family: FeS-thio- and glutaredoxins<br>12. Glutathione and glutathione-dependent enzymes<br>13. Thiol and selenol-based peroxidases: Structure and catalytic properties <br>14. Thiol peroxidase-based redox relays <br>15. Compartmentalized disulphide bond formation pathways <br>16. Disulfide bond formation in Escherichia coli<br>17. Thiol-based redox probes<br>18. Selenocysteine-containing proteins<br>19. Overview of cysteine metabolism<br>20. Hydrogen sulfide and persulfides<br>21. The role of thiols in iron-sulfur cluster biogenesis<br>22. Thiol-based redox control in chloroplasts<br>23. Sugar-based cysteine thiols recruited for oxidative stress defence and redox regulation<br>24. Polyamine-based thiols in pathogens<br>25. Thiols in blood<br>26. A thiol chemistry perspective on redox medicine<br>27. Therapeutic applications of low-molecular-weight thiols and selenocompounds<br>28. Thiol targets in drug development to combat bacterial infections<br></p>