PART 1 Structure and Function of Bone, Joints, and Connective Tissue<br>1 Developmental Biology, Organization, and Function of the Synovial Joints<br>2 Synovium<br>3 Cartilage and Chondrocytes<br>4 Development and Biology of Bone<br>5 Muscle Anatomy, Physiology, and Biochemistry<br>6 Biomechanics<br>7 Regenerative Medicine and Tissue Engineering<br>8 Proteinases and Matrix Degradation<br><br>PART 2 Cells Involved in Autoimmune Diseases and Inflammation<br>9 Dendritic Cells<br>10 Mononuclear Phagocytes<br>11 Neutrophils<br>12 T Lymphocytes<br>13 B Cells<br>14 Fibroblasts andFibroblast-like Synoviocytes<br>15 Mast Cells and Basophils<br>16 Innate Lymphoid Cells and Natural Killer Cells<br>17 Platelets and Megakaryocytes<br><br>PART 3 Effector Mechanisms in Autoimmunity and Inflammation <br>18 Principles of Signaling<br>19 Innate Immunity<br>20 Adaptive Immunity<br>21 Immune Tolerance and Autoimmunity<br>22 Pre-clinical Autoimmunity<br>23 The Microbiome in Rheumatic Diseases<br>24 Genetics of Rheumatic Diseases<br>25 Epigenetics of Rheumatic Diseases<br>26 Complement System<br>27 Prostaglandins, Leukotrienes, and Related Compounds<br>28 Angiogenesis<br>29 Cytokines and Chemokines<br>30 Neuronal Mechanisms of Pain and Inflammation<br><br>PART 4 Broad Issues in the Approach to Rheumatic Disease<br>31 Clinical Research Methods in the Rheumatic Diseases<br>32 Epidemiology and Impact of Rheumatic Diseases<br>33 Assessment of Health Outcomes<br>34 Biomarkers in Rheumatology<br>35 Occupational, Environmental, and Recreational Musculoskeletal Disorders<br>36 Cardiovascular Risk in Inflammatory Rheumatic Disease<br>37 Cancer Risk in Rheumatic Diseases<br>38 Occupational Therapy, Physical Therapy, and Rehabilitation<br>39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment<br><br>PART 5 Evaluation of Generalized and Localized Symptoms<br>40 History and Physical Examination of the Musculoskeletal System<br>41 Ultrasound in Rheumatology<br>42 Evaluation of Monoarticular and Polyarticular Arthritis<br>43 Skin and Rheumatic Diseases<br>44 The Eye and Rheumatic Diseases<br><br>PART 6 Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain<br>45 Neck Pain<br>46 Shoulder Pain<br>47 Low Back Pain<br>48 Hip and Knee Pain<br>49 Foot and Ankle Pain<br>50 Hand and Wrist Pain<br>51 Temporomandibular Joint Disorders<br>52 Fibromyalgia<br><br>PART 7 Diagnostic Tests and Procedures in Rheumatic Diseases<br>53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology<br>54 Arthrocentesis and Injection of Joints and Soft Tissues<br>55 Anti-nuclear Antibodies<br>56 Autoantibodies in Rheumatoid Arthritis<br>57 Acute Phase Reactants<br>58 Imaging in Rheumatic Diseases<br><br>PART 8 Pharmacology of Anti-rheumatic Drugs<br>59 Therapeutic Targeting of Prostanoids<br>60 Glucocorticoid Therapy<br>61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies<br>62 Immunosuppressive Drugs<br>63 Anti-cytokine Biologics<br>64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics<br>65 Janus Kinase and Other Intra-cellular Targets<br>66 Urate-Lowering Therapy<br>67 Bisphosphonates<br>68 Analgesic Agents in Rheumatic Disease<br>69 Nutrition and Rheumatic Diseases<br><br>PART 9 Rheumatoid Arthritis and Sjögren’s Syndrome<br>70 Etiology of Rheumatoid Arthritis<br>71 Pathogenesis of Rheumatoid Arthritis<br>72 Clinical Features of Rheumatoid Arthritis<br>73 Treatment of Rheumatoid Arthritis<br>74 Sjögren’s Syndrome<br><br>PART 10 Spondyloarthritis<br>75 Classification and Epidemiology of Spondyloarthritis<br>76 Axial Spondyloarthritis<br>77 Reactive Arthritis<br>78 Psoriatic Arthritis<br>79 Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic Arthropathies<br><br>PART 11 Systemic Lupus Erythematosus and Related Syndromes<br>80 Etiology and Pathogenesis of Systemic Lupus Erythematosus<br>81 Clinical Features of Systemic Lupus Erythematosus<br>82 Treatment of Systemic Lupus Erythematosus<br>83 Antiphospholipid Syndrome<br><br>PART 12 Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes<br>84 Etiology and Pathogenesis of Systemic Sclerosis<br>85 Clinical Features and Treatment of Scleroderma<br>86 Inflammatory Diseases of Muscle and Other Myopathies<br>87 Overlap Syndromes<br><br>PART 13 Vasculitis<br>88 Classification and Epidemiology of Systemic Vasculitis<br>89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis<br>90 Anti-neutrophil Cytoplasmic Antibody–Associated Vasculitis<br>91 Polyarteritis Nodosa<br>92 Immune Complex–Mediated Small Vessel Vasculitis<br>93 Primary Central Nervous System Vasculitis<br>94 Behçet’s Disease<br><br>PART 14 Crystal-Induced and Inflammasome-Mediated Inflammation<br>95 Pathogenesis of Inflammasome-Mediated Diseases<br>96 Etiology and Pathogenesis of Hyperuricemia and Gout<br>97 Clinical Features and Treatment of Gout<br>98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes<br>99 Familial and Nonfamilial Autoinflammatory Syndromes<br><br>PART 15 Cartilage, Bone, and Heritable Connective Tissue Disorders<br>100 Etiology and Pathogenesis of Osteoarthritis<br>101 Clinical Features of Osteoarthritis<br>102 Treatment of Osteoarthritis<br>103 Metabolic Bone Disease<br>104 Proliferative Bone Diseases<br>105 Osteonecrosis<br>106 Relapsing Polychondritis<br>107 Heritable Diseases of Connective Tissues<br><br>PART 16 Rheumatic Diseases of Childhood<br>108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis<br>109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis<br>110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus<br>111 Juvenile Dermatomyositis, Scleroderma, and Vasculitis<br><br>PART 17 Infections and Rheumatic Disease<br>112 Bacterial Arthritis<br>113 Lyme Disease<br>114 Mycobacterial Infections of Bones and Joints<br>115 Fungal Infections of Bones and Joints<br>116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection<br>117 Viral Arthritis<br>118 Rheumatic Fever and Post-streptococcal Arthritis<br>119 COVID-19 and Rheumatic Disease<br>120 Vaccination in Rheumatic Disease<br><br>PART 18 Arthritis Accompanying Systemic Disease<br>121 Amyloidosis<br>122 Sarcoidosis<br>123 Hemochromatosis<br>124 Hemophilic Arthropathy<br>125 Rheumatic Manifestations of Hemoglobinopathies<br>126 IgG4-Related Disease<br>127 Arthritis Accompanying Endocrine and Metabolic Disorders<br>128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations<br>129 Tumors and Tumor-like Lesions of Joints and Related Structures<br>130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer