X. William Yang,
Xiangdong William Yang,
Myriam Heiman,
Leslie M. Thompson
e.a.
Elsevier Science
e druk, 2024
9780323956727
Huntington’s Disease
Pathogenic Mechanisms and Implications for Therapeutics
Specificaties
Paperback, blz.
|
Engels
Elsevier Science |
2024
ISBN13: 9780323956727
Rubricering
Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical triad of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge thinking on therapeutic strategies for HD. Chapters explore areas that include the clinical features and genetic studies of HD, the cellular and molecular biology of normal huntingtin, a range of HD models, the diverse pathogenic mechanisms linked to mutant huntingtin, new approaches to HD pathogenesis, as well as emerging preclinical therapeutic approaches and clinical programs in the field.
Specificaties
Inhoudsopgave
<p>1. Huntington’s Disease: Clinical Features, Genetic Diagnosis, and Brain Imaging<br>Carlos Estevez-Fraga, Mitsuko Nakajima and Sarah J. Tabrizi<br>2. Revolutionizing Clinical Research and Communication in Huntington’s Disease: The Huntington’s Disease Integrated Staging System (HD-ISS)<br>Cristina Sampaio, Jeffrey D. Long, Alexandra Mansbach, Sarah J. Tabrizi, Emily C. Gantman<br>3. Huntington’s Disease Genetics: Implications for Pathogenesis<br>Marcy E. Macdonald, Jong-Min Lee and James F. Gusella<br>4. The Instability of the Huntington’s Disease CAG Repeat Mutation<br>Vanessa C. Wheeler, Joseph C. Stone, Thomas H. Massey and Ricardo Mouro Pinto<br>5. Mechanisms of Somatic CAG -Repeat Expansions in Huntington’s Disease<br>Amit L. Deshmukh, Terence Gall-Duncan and Christopher E. Pearson<br>6. RNA-Mediated Pathogenic Mechanisms in Huntington’s Disease<br>Gillian P. Bates, Sandra Fienko, Christian Landles and Aikaterini-Smaragdi Papadopoulou<br>7. Huntingtin Protein-protein Interactions: From Biology to Therapeutic Targets<br>Eduardo Silva Ramos, Todd M. Greco, Ileana M. Cristea and Erich E. Wanker<br>8. Repeat-Associated Non-AUG (RAN) Translation and Huntington’s Disease: Pathology, Mechanistic and Therapeutic Perspectives<br>Monica Banez-Coronel, John Douglas Cleary and Laura P.W. Ranum<br>9. Proteostasis Function and Dysfunction in Huntington’s Disease<br>Juliana Abramovich, Korbin Kleczko, Vincent Masto and Judith Frydman<br>10. Autophagy and Huntington’s Disease<br>Katherine R. Croce, Hilary Grosso Jasutkar and Ai Yamamoto<br>11. SUMO Modification in Huntington’s Disease: Unraveling Complex Mechanisms for Therapeutic Insights<br>Charlene Smith, Joan S. Steffan and Leslie M. Thompson<br>12. Selective Vulnerability in Huntington’s Disease: From Excitotoxicity, Mitochondrial<br>Dysfunction, and Transcription Dysregulation to Therapeutic Opportunity<br>Jacob S. Deyell, Ravinder Gulia and Albert R. La Spada<br>13. Pathophysiology of Synapses and Circuits in Huntington Disease<br>Marja D. Sepers, James Mackay and Lynn A. Raymond<br>14. The Role of Glial Pathology in Huntington’s Disease<br>Steven A. Goldman<br>15. Systems Biology Study of Huntington’s Disease<br>Leonardo E. Dionisio, Peter Langfelder, Jeffrey S. Aaronson, Jim Rosinski and X. William Yang<br>16. Unbiased Genome-Wide Approaches to Identify Vulnerability Factors in Huntington’s Disease<br>Suphinya Sathitloetsakun and Myriam Heiman<br>17. Striatal Neuronal Models of Huntington’s Disease Via Direct Conversion: Modeling Age-dependent Disease Phenotypes<br>Young Mi Oh, Seong Won Lee and Andrew S. Yoo<br>18. Genetic Mouse Models to Explore Huntington’s Disease Mechanisms and Therapeutic Strategies<br>Michelle Gray, Scott O. Zeitlin, Aida Moran-Reyna and Jeh-Ping Liu<br>19. Huntington’s Disease: From Large Animal Models to HD Gene Therapy<br>Sen Yan, Xiao-Jiang Li and Shihua Li<br>20. Deep Learning and Deep Phenotyping of HD iPSCs: Applications to Study Biology and Test Therapeutics<br>Steven Finkbeiner<br>21. The Promise of an Underappreciated Therapeutic Target: Sleep and Circadian Rhythm Dysfunction in Huntington’s Disease<br>Christopher S. Colwell, Weiyi Tan and A. Jennifer Morton<br>22. Huntingtin Lowering Therapeutics<br>Neil Aronin, Miguel E. Sena-Esteves, Anastasia Khvorova, Marian Difiglia and Michael Brodsky<br>23. Gene Editing for HD: Therapeutic Prospects<br>Richard Z. Chen and Thomas F. Vogt<br>24. Current Clinical Trials of New Therapeutic Agents for Huntington’s Disease<br>Blair R. Leavitt</p>