Contributors <br>About the editors <br>Preface <br>UDINE 2023 <br>Objective of this volume <br>Highlights <br><br>I General introduction<br><br>1. Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgery<br>Signori Davide, Mattias Carlström, Lorenzo Berra, and Rezoagli Emanuele<br><br>Abbreviations <br>Introduction <br>Pathophysiology of CSA-AKI and NO dysregulation <br>Renal vasoconstriction <br>Direct free-hemoglobin and catalytic iron injury <br>Ischemiaereperfusion injury <br>Conclusions <br>Conflict of interest statement <br>Acknowledgments <br>References <br><br>II Nitric oxide and cancer<br><br>2. The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancer<br>Arduino A. Mangoni, Lashika Weerakoon, Vinitha N. Ragavan, Natalia Jarzebska, Roman N. Rodionov, and Sara Tommasi<br><br>Abbreviations <br>Introduction <br>Vasculogenic mimicry: Pathogenesis and clinical significance <br>Dimethylarginine dimethylaminohydrolase 1: Biology and role in vasculogenic mimicry <br>Recent developments in understanding the biological role of DDAH2 and its possible effects in vasculogenic mimicry <br>General considerations <br>Conflict of interest statement <br>References<br><br>III Nitric oxide reactions in the cells and models to check its biological properties<br><br>3. Decoding S-nitrosylation: Theoretical aspects and analytical approaches<br>Gianmarco Matrullo, Chiara Pecorari, and Giuseppe Filomeni<br><br>Abbreviations <br>Introduction <br>NO signaling <br>Nitric oxide in physiology and pathology <br>S-nitrosylation detection: Approaches and challenges <br>Conclusion <br>Conflict of interest <br>Acknowledgments <br>References <br><br>4. Preclinical models to assess the pharmacological properties of NO derivatives<br>Lucia Morbidelli and Valerio Ciccone<br><br>Abbreviations <br>From preclinical to clinical trials of drugs <br>Cell-based in vitro pharmacological screening and safety assessment <br>Ex vivo experiments <br>In vivo experiments to assess efficacy and safety of NO derivatives <br>Conclusions <br>Acknowledgements <br>References <br><br>IV<br>Nitric oxide and neurodegeneration<br><br>5. Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration<br>Jennifer Cale, Tracy D. Farr, Sebastien Serres, and Joern R. Steinert<br><br>Abbreviations <br>Introduction <br>Neurovascular oxidative and nitrergic stress <br>Redox stress in the vascular, neuronal, and astrocytic compartments <br>Therapeutic targets of NO signaling <br>Conclusions <br>Acknowledgments <br>References <br><br>V Nitric oxide and therapeutics<br><br>6. Role of nitric oxide in gemcitabine resistance in pancreatic cancer cells<br>Mariachiara Gani, Eros Di Giorgio, Raffaella Picco, Luigi E. Xodo, and Valentina Rapozzi<br><br>Abbreviations <br>Introduction <br>Acknowledgments <br>References <br>Further reading <br><br>7. Exploring the dual role of nitric oxide in glioblastoma: Therapeutic implications<br>Inesa Navasardyan and Benjamin Bonavida<br><br>Abbreviations <br>Introduction <br>Treatment of GBM <br>NO production and its biological process <br>Role of the INOS/NO pathway in GBM <br>NO-targeted therapies in GBM <br>Discussion <br>Perspectives and future directions <br>Acknowledgments <br>References <br><br>8. Nitric oxide donating systems and their potential in shaping tumor immunoregulation<br>Greta Varchi<br><br>Introduction <br>The tumor microenvironment <br>The enigmatic dual nature of nitric oxide in cancer <br>Nitric oxide donors <br>Nitric oxide donors and the immune system <br>Conclusions and future directions <br>References <br><br>9. Control of nitric oxide synthase 2: Role of NRF2-regulated distal enhancer<br>Eros Di Giorgio, Valentina Rapozzi, and Luigi E. Xodo<br><br>Abbreviations <br>Introduction <br>NOS2 structure and function <br>NOS2 and cancer <br>Transcription factors activating NOS2 expression <br>NRF2 controls the expression of NOS2 <br>RF2 binds to a distal enhancer of NOS2 <br>PDAC-spheroids formation depends on NOS2: Therapeutic implications <br>Concluding remarks <br>Conflict of interest <br>References <br>Further Reading <br><br>10. Nitric oxide in tumor biology: From stemness to metabolic reprogramming<br>Antonio Rodríguez-Ariza<br><br>Abbreviations<br>Introduction<br>Role of NO in the acquisition of stem characteristics and therapy resistance in breast cancer<br>Role of NO in the biology of intestinal cancer cells<br>Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer<br>Conclusions<br>Acknowledgments<br>References<br><br>11. Impact of nitric oxide on hemeprotein maturation and its relevance to cancer and pulmonary diseases<br>Chaitali Ghosh, Mamta Sumi, and Arnab Ghosh<br><br>Abbreviations<br>Introduction <br>Impact of NO on hemeprotein maturation<br>NO in cancer<br>Significance of the NO-sGC-cGMP pathway in globin maturation and relevance to cancer progression<br>NO in asthma and pulmonary diseases<br>Conclusion and future directions<br>Acknowledgments<br>References<br><br>VI Educational session<br><br>12. Using artificial intelligence to discover new cancer therapies<br>Apostolos Zaravinos<br><br>Index 000
