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Pathophysiological Aspects of Proteases in Cancer

Specificaties
Paperback, blz. | Engels
Elsevier Science | 2024
ISBN13: 9780443300981
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Elsevier Science e druk, 2024 9780443300981
€ 197,79
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Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.

Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.

Specificaties

ISBN13:9780443300981
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

Section I: General Aspects<br>1. Pathophysiological aspects of calpains in cancer<br>2. Mitochondrial proteases in cancer development and progression<br>3. Proteases in Head and Neck Cancer<br>4. Matrix metalloproteases and uveal melanomas<br>5. Proteases in DNA damage, repair and radio resistance: Cellular and Molecular aspects<br>6. Radiotherapy, proteases and gastric cancer: a complex interplay<br>7. Matrix metalloproteases in the pathogenesis of hepatocarcinoma<br>8. Exploring synthetic and natural compounds for Cathepsin B: Mechanisms and therapy<br>9. Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer<br>10. Ubiquitin –specific protease 3,7 in bone cancer and squamous cell carcinoma<br>11. Serine protease: structure, classification, mechanism and role in breast cancer<br> <br>Section II: Proteases as Diagnostics and Prognostics Biomarkers<br>12. Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and novel therapeutic targets for gastric cancer<br>13. Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer<br>14. From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis<br>15. Cathepsins as a diagnostic and prognostic marker in Oral cancer<br>16. Role of Kallikreins in Prostate Cancer<br>17. Mechanistic aspects of Serine Protease as biomarkers in wound healing of lung cancer<br>18. The role of acetylcholinesterase in cancer development and possible therapeutic applications<br>19. Therapeutics of animal derived compounds in proteases induced cancer<br>20. Molecular Warriors: Proteases as Sentinels in the War Against Cancer Diagnosis and Prognosis<br> <br>Section III: Proteases, Chemoresistance and Cancer<br>21. Serine proteases, chemoresistance and cancer<br>22. Cathepsins, chemoresistance and cancer<br>23. ix metalloproteases, chemoresistance and cancer<br>24. MMPs (-2 and -9) mediated drug resistance and their reversal in gynecological cancer<br>25. The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer<br>26. Role of the proteasome in the development of chemoresistance in multiple myeloma<br>27. Role of cysteine cathepsin and matrix metalloproteases in progression and chemoresistance in ovarian and breast cancer<br>28. Proteases, chemoresistance and cancer<br>29. Breaking Barriers: Proteases as Key Players in Cancer Chemoresistance<br> <br>Section IV: Other Aspects<br>30. Matrix metalloproteases-targeting low molecular weight compound<br>31. Synthetic protease inhibitors in oral, head and neck cancer: evidence from clinical trials.<br>32. Synthetic protease inhibitors in endocrine and gastroenterology cancers: results of clinical trials<br>33. Side effects of synthetic protease inhibitors used in gynecology cancers<br>34. Role of synthetic compounds with protease inhibitory activity in breast cancer<br>35. Cathepsin responsive nanomaterials for targeted delivery of malignant tumors
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        Pathophysiological Aspects of Proteases in Cancer