J. G. (University of Surrey) Salway,
JG Salway
John Wiley & Sons
3e druk, 2012
9780470654514
Medical Biochemistry at a Glance
Specificaties
Paperback, 176 blz.
|
Engels
John Wiley & Sons |
3e druk, 2012
ISBN13: 9780470654514
Rubricering
Onderdeel van serie
At a Glance
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Offering a concise, illustrated summary of biochemistry and its relevance to clinical medicine,
Medical Biochemistry at a Glance is intended for students of medicine and the biomedical sciences such as nutrition, biochemistry, sports science, medical laboratory sciences, physiotherapy, pharmacy, physiology, pharmacology, genetics and veterinary science. It also provides a succinct review and reference for medical practitioners and biomedical scientists who need to quickly refresh their knowledge of medical biochemistry.
The book is designed as a revision guide for students preparing for examinations and contains topics that have been identified as ′high–yield′ facts for the United States Medical Licensing Examination (USMLE), Step 1.
This third edition:
Has been thoroughly revised and updated and is now in full colour throughout
Is written by the author of the hugely successful Metabolism at a Glance (ISBN 9781405107167)
Features updated and improved clinical correlates
Expands its coverage with a new section on Molecular Biology
Includes a brand new companion website of self–assessment questions and answers at www.ataglanceseries.com/medicalbiochemistry
Specificaties
ISBN13:9780470654514
Taal:Engels
Bindwijze:paperback
Aantal pagina's:176
Uitgever:John Wiley & Sons
Druk:3
Serie:At a Glance
Inhoudsopgave
Preface to the third edition 7
<p>Acknowledgements to the third edition 7</p>
<p>Figure key 8</p>
<p>SI/mass unit conversions 9</p>
<p>Part 1 Acids, bases and pH</p>
<p>1 Acids, bases and hydrogen ions (protons) 10</p>
<p>2 Understanding pH 12</p>
<p>3 Production and removal of protons into and from the blood 14</p>
<p>4 Metabolic alkalosis and metabolic acidosis 16</p>
<p>5 Respiratory alkalosis and respiratory acidosis 18</p>
<p>Part 2 Structure of amino acids and proteins</p>
<p>6 Amino acids and the primary structure of proteins 20</p>
<p>7 Secondary structure of proteins 22</p>
<p>8 Tertiary and quaternary structure and collagen 24</p>
<p>Part 3 Formation of ATP: oxidation and reduction reactions</p>
<p>9 Oxidation/reduction reactions, coenzymes and prosthetic groups 26</p>
<p>10 Anaerobic production of ATP by substrate–level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction 28</p>
<p>11 Aerobic production of ATP 30</p>
<p>12 Biosynthesis of ATP by oxidative phosphorylation I 32</p>
<p>13 Biosynthesis of ATP by oxidative phosphorylation II 34</p>
<p>14 What happens when protons or electrons leak from the respiratory chain? 36</p>
<p>15 Free radicals, reactive oxygen species and oxidative damage 38</p>
<p>16 Aerobic oxidation of glucose to provide energy as ATP 40</p>
<p>17 Anaerobic oxidation of glucose by glycolysis to form ATP and lactate 42</p>
<p>18 Anaerobic glycolysis in red blood cells, 2,3–BPG (2,3–DPG) and the Bohr effect 44</p>
<p>Part 4 Carbohydrates</p>
<p>19 Carbohydrates 46</p>
<p>20 Absorption of carbohydrates and metabolism of galactose 48</p>
<p>21 Fate of glucose in liver: glycogenesis and lipogenesis 50</p>
<p>22 Fructose metabolism 52</p>
<p>23 Glucose homeostasis 54</p>
<p>24 Glucose–stimulated secretion of insulin from –cells 56</p>
<p>25 Regulation of glycogen metabolism 58</p>
<p>26 Glycogen breakdown (glycogenolysis) and glycogen storage diseases 60</p>
<p>27 Insulin signal transduction and diabetes mellitus 62</p>
<p>28 Diabetes mellitus 64</p>
<p>29 Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis 66</p>
<p>Part 5 Enzymes and regulation of pathways</p>
<p>30 Enzymes: nomenclature, kinetics and inhibitors 68</p>
<p>31 Regulation of enzyme activity 70</p>
<p>32 Regulation of glycolysis and Krebs cycle 72</p>
<p>33 Oxidation of fatty acids to produce ATP in muscle and ketone bodies in liver 74</p>
<p>34 Regulation of lipolysis, –oxidation, ketogenesis and gluconeogenesis 76</p>
<p>Part 6 Lipids and lipid metabolism</p>
<p>35 Structure of lipids 78</p>
<p>36 Phospholipids I: phospholipids and sphingolipids 80</p>
<p>37 Phospholipids II: micelles, liposomes, lipoproteins and membranes 82</p>
<p>38 Metabolism of carbohydrate to cholesterol 84</p>
<p>39 VLDL and LDL metabolism I: forward cholesterol transport 86</p>
<p>40 VLDL and LDL metabolism II: endogenous triacylglycerol transport 88</p>
<p>41 HDL metabolism: reverse cholesterol transport 90</p>
<p>42 Absorption and disposal of dietary triacylglycerols and cholesterol by chylomicrons 92</p>
<p>43 Steroid hormones: aldosterone, cortisol, androgens and oestrogens 94</p>
<p>Part 7 Metabolism of amino acids and porphyrins</p>
<p>44 Urea cycle and overview of amino acid catabolism 96</p>
<p>45 Non–essential and essential amino acids 98</p>
<p>46 Amino acid metabolism: to energy as ATP; to glucose and ketone bodies 100</p>
<p>47 Amino acid disorders: maple syrup urine disease, homocystinuria, cystinuria, alkaptonuria and albinism 102</p>
<p>48 Phenylalanine and tyrosine metabolism in health and disease 104</p>
<p>49 Products of tryptophan and histidine metabolism 106</p>
<p>50 Haem, bilirubin and porphyria 108</p>
<p>Part 8 Vitamins</p>
<p>51 Fat–soluble vitamins I: vitamins A and D 110</p>
<p>52 Fat–soluble vitamins II: vitamins E and K 112</p>
<p>53 Water–soluble vitamins I: thiamin, ribofl avin, niacin and pantothenate 114</p>
<p>54 Water–soluble vitamins II: pyridoxal phosphate (B6) 116</p>
<p>55 Water–soluble vitamins III: folate and vitamin B12 118</p>
<p>56 Water–soluble vitamins IV: biotin and vitamin C 120</p>
<p>Part 9 Molecular biology</p>
<p>57 The cell cycle 122</p>
<p>58 Pyrimidine metabolism 124</p>
<p>59 Purine metabolism 126</p>
<p>60 Structure of DNA 128</p>
<p>61 The central dogma of molecular biology 130</p>
<p>62 Organisation of DNA in chromosomes 132</p>
<p>63 Replication of DNA (part 1) 134</p>
<p>64 Replication of DNA (part 2) 136</p>
<p>65 DNA damage and repair 138</p>
<p>66 Transcription of DNA to make messenger RNA (part 1) 140</p>
<p>67 Transcription of DNA to make messenger RNA (part 2) 142</p>
<p>68 Transcription of DNA to make transfer RNA 144</p>
<p>69 Transcription of DNA to make ribosomal RNA 146</p>
<p>70 Translation and protein synthesis 148</p>
<p>71 Comparison of DNA replication, DNA transcription and protein synthesis in eukaryotes and prokaryotes 150</p>
<p>Part 10 Diagnostic clinical biochemistry</p>
<p>72 Diagnostic clinical biochemistry (with Dr J. W. Wright FRCP, MRCPath) 152</p>
<p>Index 154</p>
<p>Acknowledgements to the third edition 7</p>
<p>Figure key 8</p>
<p>SI/mass unit conversions 9</p>
<p>Part 1 Acids, bases and pH</p>
<p>1 Acids, bases and hydrogen ions (protons) 10</p>
<p>2 Understanding pH 12</p>
<p>3 Production and removal of protons into and from the blood 14</p>
<p>4 Metabolic alkalosis and metabolic acidosis 16</p>
<p>5 Respiratory alkalosis and respiratory acidosis 18</p>
<p>Part 2 Structure of amino acids and proteins</p>
<p>6 Amino acids and the primary structure of proteins 20</p>
<p>7 Secondary structure of proteins 22</p>
<p>8 Tertiary and quaternary structure and collagen 24</p>
<p>Part 3 Formation of ATP: oxidation and reduction reactions</p>
<p>9 Oxidation/reduction reactions, coenzymes and prosthetic groups 26</p>
<p>10 Anaerobic production of ATP by substrate–level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction 28</p>
<p>11 Aerobic production of ATP 30</p>
<p>12 Biosynthesis of ATP by oxidative phosphorylation I 32</p>
<p>13 Biosynthesis of ATP by oxidative phosphorylation II 34</p>
<p>14 What happens when protons or electrons leak from the respiratory chain? 36</p>
<p>15 Free radicals, reactive oxygen species and oxidative damage 38</p>
<p>16 Aerobic oxidation of glucose to provide energy as ATP 40</p>
<p>17 Anaerobic oxidation of glucose by glycolysis to form ATP and lactate 42</p>
<p>18 Anaerobic glycolysis in red blood cells, 2,3–BPG (2,3–DPG) and the Bohr effect 44</p>
<p>Part 4 Carbohydrates</p>
<p>19 Carbohydrates 46</p>
<p>20 Absorption of carbohydrates and metabolism of galactose 48</p>
<p>21 Fate of glucose in liver: glycogenesis and lipogenesis 50</p>
<p>22 Fructose metabolism 52</p>
<p>23 Glucose homeostasis 54</p>
<p>24 Glucose–stimulated secretion of insulin from –cells 56</p>
<p>25 Regulation of glycogen metabolism 58</p>
<p>26 Glycogen breakdown (glycogenolysis) and glycogen storage diseases 60</p>
<p>27 Insulin signal transduction and diabetes mellitus 62</p>
<p>28 Diabetes mellitus 64</p>
<p>29 Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis 66</p>
<p>Part 5 Enzymes and regulation of pathways</p>
<p>30 Enzymes: nomenclature, kinetics and inhibitors 68</p>
<p>31 Regulation of enzyme activity 70</p>
<p>32 Regulation of glycolysis and Krebs cycle 72</p>
<p>33 Oxidation of fatty acids to produce ATP in muscle and ketone bodies in liver 74</p>
<p>34 Regulation of lipolysis, –oxidation, ketogenesis and gluconeogenesis 76</p>
<p>Part 6 Lipids and lipid metabolism</p>
<p>35 Structure of lipids 78</p>
<p>36 Phospholipids I: phospholipids and sphingolipids 80</p>
<p>37 Phospholipids II: micelles, liposomes, lipoproteins and membranes 82</p>
<p>38 Metabolism of carbohydrate to cholesterol 84</p>
<p>39 VLDL and LDL metabolism I: forward cholesterol transport 86</p>
<p>40 VLDL and LDL metabolism II: endogenous triacylglycerol transport 88</p>
<p>41 HDL metabolism: reverse cholesterol transport 90</p>
<p>42 Absorption and disposal of dietary triacylglycerols and cholesterol by chylomicrons 92</p>
<p>43 Steroid hormones: aldosterone, cortisol, androgens and oestrogens 94</p>
<p>Part 7 Metabolism of amino acids and porphyrins</p>
<p>44 Urea cycle and overview of amino acid catabolism 96</p>
<p>45 Non–essential and essential amino acids 98</p>
<p>46 Amino acid metabolism: to energy as ATP; to glucose and ketone bodies 100</p>
<p>47 Amino acid disorders: maple syrup urine disease, homocystinuria, cystinuria, alkaptonuria and albinism 102</p>
<p>48 Phenylalanine and tyrosine metabolism in health and disease 104</p>
<p>49 Products of tryptophan and histidine metabolism 106</p>
<p>50 Haem, bilirubin and porphyria 108</p>
<p>Part 8 Vitamins</p>
<p>51 Fat–soluble vitamins I: vitamins A and D 110</p>
<p>52 Fat–soluble vitamins II: vitamins E and K 112</p>
<p>53 Water–soluble vitamins I: thiamin, ribofl avin, niacin and pantothenate 114</p>
<p>54 Water–soluble vitamins II: pyridoxal phosphate (B6) 116</p>
<p>55 Water–soluble vitamins III: folate and vitamin B12 118</p>
<p>56 Water–soluble vitamins IV: biotin and vitamin C 120</p>
<p>Part 9 Molecular biology</p>
<p>57 The cell cycle 122</p>
<p>58 Pyrimidine metabolism 124</p>
<p>59 Purine metabolism 126</p>
<p>60 Structure of DNA 128</p>
<p>61 The central dogma of molecular biology 130</p>
<p>62 Organisation of DNA in chromosomes 132</p>
<p>63 Replication of DNA (part 1) 134</p>
<p>64 Replication of DNA (part 2) 136</p>
<p>65 DNA damage and repair 138</p>
<p>66 Transcription of DNA to make messenger RNA (part 1) 140</p>
<p>67 Transcription of DNA to make messenger RNA (part 2) 142</p>
<p>68 Transcription of DNA to make transfer RNA 144</p>
<p>69 Transcription of DNA to make ribosomal RNA 146</p>
<p>70 Translation and protein synthesis 148</p>
<p>71 Comparison of DNA replication, DNA transcription and protein synthesis in eukaryotes and prokaryotes 150</p>
<p>Part 10 Diagnostic clinical biochemistry</p>
<p>72 Diagnostic clinical biochemistry (with Dr J. W. Wright FRCP, MRCPath) 152</p>
<p>Index 154</p>