JJ Jones
John Wiley & Sons
e druk, 2012
9780470711613
Bio–Glasses – An Introduction
An Introduction
Specificaties
Gebonden, 254 blz.
|
Engels
John Wiley & Sons |
2012
ISBN13: 9780470711613
Rubricering
Verwachte levertijd ongeveer 16 werkdagen
Samenvatting
This new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio–glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells.
Key features:
First book on biomaterials to focus on bio–glasses
Edited by a leading authority on bio–glasses trained by one of its inventors, Dr Larry Hench
Supported by the International Commission on Glass (ICG)
Authored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbook
Written in an accessible style to facilitate rapid absorption of information
Covers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current procedures
Of interest to the biomedical as well as the materials science community.
The book covers all types of glasses: traditional glasses, bioactive glasses, sol–gel glasses, phosphate glasses, glass–ceramics, composites and hybrids. Alongside discussion on how bio–glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale–up, quality assurance and FDA approval.
Specificaties
Inhoudsopgave
<p>List of Contributors xi</p>
<p>Foreword xiii</p>
<p>Preface xvii</p>
<p>1 The Unique Nature of Glass 1<br /> Alexis G. Clare</p>
<p>1.1 What is Glass? 1</p>
<p>1.2 Making Glass 5</p>
<p>1.3 Homogeneity and Phase Separation 8</p>
<p>1.4 Forming 9</p>
<p>1.5 Glasses that are not "Melted" 10</p>
<p>1.6 Exotic Glass 11</p>
<p>1.7 Summary 11</p>
<p>2 Melt–Derived Bioactive Glass 13<br /> Matthew D. O′Donnell</p>
<p>2.1 Bioglass 13</p>
<p>2.2 Network Connectivity and Bioactivity 18</p>
<p>2.3 Alternative Bioactive Glass Compositions 19</p>
<p>2.4 In Vitro Studies 22</p>
<p>2.5 In Vivo Studies and Commercial Products 22</p>
<p>3 Sol Gel Derived Glasses for Medicine 29<br /> Julian R. Jones</p>
<p>3.1 Introduction 29</p>
<p>3.2 Why Use the Sol Gel Process? 30</p>
<p>3.3 Sol Gel Process Principles 31</p>
<p>3.4 Steps in a Typical Sol Gel Process 32</p>
<p>3.5 Evolution of Nanoporosity 36</p>
<p>3.6 Making Sol Gel Monoliths 37</p>
<p>3.7 Making Particles 38</p>
<p>3.8 Sol Gel Derived Bioactive Glasses 40</p>
<p>3.9 Summary 42</p>
<p>4 Phosphate Glasses 45<br /> Delia S. Brauer</p>
<p>4.1 Introduction 45</p>
<p>4.2 Making Phosphate Glasses 46</p>
<p>4.3 Phosphate Glass Structure 46</p>
<p>4.4 Temperature Behaviour and Crystallisation 50</p>
<p>4.5 Phosphate Glass Dissolution 56</p>
<p>4.6 Cell Compatibility of Glasses 59</p>
<p>4.7 Phosphate Glass Fibres and Composites 60</p>
<p>4.8 Applications 62</p>
<p>4.9 Summary 63</p>
<p>5 The Structure of Bioactive Glasses and Their Surfaces 67<br /> Alastair N. Cormack</p>
<p>5.1 Structure of Glasses 67</p>
<p>5.2 Structure of Bioactive Glasses 70</p>
<p>5.3 Computer Modeling (Theoretical Simulation) of Bioactive Glasses 71</p>
<p>5.4 Glass Surfaces 74</p>
<p>5.5 Summary 76</p>
<p>6 Bioactive Borate Glasses 77<br /> Steven B. Jung</p>
<p>6.1 Introduction 77</p>
<p>6.2 What Differentiates a Bioactive Borate Glass from Other Bioactive Glasses? 78</p>
<p>6.3 Evaluating Reactive Materials (</p>
<p>6.4 Multifunctional Bioactive Borate Glasses 83</p>
<p>6.5 Applications of Bioactive Borate Glasses in Orthopedics and Dental Regeneration 86</p>
<p>6.6 Soft Tissue Wound Healing 88</p>
<p>6.7 Tissue/Vessel Guidance 92</p>
<p>6.8 Drug Delivery 93</p>
<p>6.9 Commercial Product Design 94</p>
<p>6.10 Summary 96</p>
<p>7 Glass Ceramics 99<br /> Wolfram Holand</p>
<p>7.1 Glass Ceramics and Their Uses 99</p>
<p>7.2 Methods Used for the Controlled Crystallization of Glasses 101</p>
<p>7.3 A Glass Ceramic that Hardly Expands When Heated 103</p>
<p>7.4 High–Strength, Moldable Glass Ceramics for Dental Restoration 104</p>
<p>7.5 Glass Ceramics that are Moldable and Machinable 106</p>
<p>7.6 Outlook 106</p>
<p>8 Bioactive Glass and Glass Ceramic Coatings 109<br /> Enrica Verne</p>
<p>8.1 Introduction 109</p>
<p>8.2 Enameling 110</p>
<p>8.3 Glazing 114</p>
<p>8.4 Plasma Spraying 117</p>
<p>8.5 Radiofrequency Magnetron Sputtering Deposition 119</p>
<p>8.6 Pulsed Laser Deposition 119</p>
<p>8.7 Summary 120</p>
<p>9 Composites Containing Bioactive Glass 123<br /> Aldo R. Boccaccini and Qi–Zhi Chen</p>
<p>9.1 Introduction 123</p>
<p>9.2 Biodegradable Polymers 127</p>
<p>9.3 Composite Scaffolds Containing Bioactive Glass 131</p>
<p>9.4 Processing Technologies for Porous Bioactive Composites 133</p>
<p>9.5 Case Study: the PDLLA Bioglass Composite Scaffold System 138</p>
<p>9.6 Final Remarks 139</p>
<p>10 Inorganic Organic Sol Gel Hybrids 141<br /> Yuki Shirosaki, Akiyoshi Osaka, Kanji Tsuru, and Satoshi Hayakawa</p>
<p>10.1 Introduction 141</p>
<p>10.2 Hybrids in Medicine and Why They Should Be Silica–Based 142</p>
<p>10.3 Self–Assembled Hybrid Films and Layers of Grafted Silanes 145</p>
<p>10.4 Sol Gel Hybrids 146</p>
<p>10.5 Ormosils 148</p>
<p>10.6 Polymer Choice and Property Control in Hybrids 151</p>
<p>10.7 Maintaining Bioactivity in Sol Gel Hybrids 154</p>
<p>10.8 Summary and Outlook 158</p>
<p>11 Dental Applications of Glasses 161<br /> Leena Hupa and Antti Yli–Urpo</p>
<p>11.1 Introduction 161</p>
<p>11.2 Structure of the Human Tooth 162</p>
<p>11.3 Glass Bioactivity and Teeth 163</p>
<p>11.4 Bioactive Glass in Dental Bone Regeneration 166</p>
<p>11.5 Treatment of Hypersensitive Teeth 168</p>
<p>11.6 Bioactive Glass Coating on Metal Implants 169</p>
<p>11.7 Antimicrobial Properties of Bioactive Glasses 172</p>
<p>11.8 Bioactive Glasses in Polymer Composites 173</p>
<p>11.9 Bioactive Glasses in Glass Ionomer Cements 174</p>
<p>11.10 Summary 175</p>
<p>12 Bioactive Glass as Synthetic Bone Grafts and Scaffolds for Tissue Engineering 179<br /> Julian R. Jones</p>
<p>12.1 Introduction 179</p>
<p>12.2 Synthetic Bone Grafts and Regenerative Medicine 181</p>
<p>12.3 Design Criteria for an Ideal Synthetic Bone Graft 183</p>
<p>12.4 Bioglass and the Complication of Crystallisation During Sintering 184</p>
<p>12.5 Making Porous Glasses 185</p>
<p>12.6 The Future: Porous Hybrids 196</p>
<p>12.7 Bioactive Glasses and Tissue Engineering 200</p>
<p>12.8 Regulatory Issues 201</p>
<p>12.9 Summary 202</p>
<p>13 Glasses for Radiotherapy 205<br /> Delbert E. Day</p>
<p>13.1 Introduction 205</p>
<p>13.2 Glass Design and Synthesis 208</p>
<p>13.3 Non–Degradable or Bio–inert Glasses: Rare Earth Aluminosilicate Glasses 208</p>
<p>13.4 Biodegradable Glasses: Rare Earth Borate/Borosilicate Glasses 211</p>
<p>13.5 Design of Radioactive Glass Microspheres for In Vivo Applications 213</p>
<p>13.6 Treatment of Liver Cancer: Hepatocellular Carcinoma 217</p>
<p>13.7 Treatment of Kidney Cancer: Renal Cellarcinoma 222</p>
<p>13.8 Treatment of Rheumatoid Arthritis: RadiationSynovectomy 223</p>
<p>13.9 Summary 227</p>
<p>References 228</p>
<p>Index 231</p>
<p>Foreword xiii</p>
<p>Preface xvii</p>
<p>1 The Unique Nature of Glass 1<br /> Alexis G. Clare</p>
<p>1.1 What is Glass? 1</p>
<p>1.2 Making Glass 5</p>
<p>1.3 Homogeneity and Phase Separation 8</p>
<p>1.4 Forming 9</p>
<p>1.5 Glasses that are not "Melted" 10</p>
<p>1.6 Exotic Glass 11</p>
<p>1.7 Summary 11</p>
<p>2 Melt–Derived Bioactive Glass 13<br /> Matthew D. O′Donnell</p>
<p>2.1 Bioglass 13</p>
<p>2.2 Network Connectivity and Bioactivity 18</p>
<p>2.3 Alternative Bioactive Glass Compositions 19</p>
<p>2.4 In Vitro Studies 22</p>
<p>2.5 In Vivo Studies and Commercial Products 22</p>
<p>3 Sol Gel Derived Glasses for Medicine 29<br /> Julian R. Jones</p>
<p>3.1 Introduction 29</p>
<p>3.2 Why Use the Sol Gel Process? 30</p>
<p>3.3 Sol Gel Process Principles 31</p>
<p>3.4 Steps in a Typical Sol Gel Process 32</p>
<p>3.5 Evolution of Nanoporosity 36</p>
<p>3.6 Making Sol Gel Monoliths 37</p>
<p>3.7 Making Particles 38</p>
<p>3.8 Sol Gel Derived Bioactive Glasses 40</p>
<p>3.9 Summary 42</p>
<p>4 Phosphate Glasses 45<br /> Delia S. Brauer</p>
<p>4.1 Introduction 45</p>
<p>4.2 Making Phosphate Glasses 46</p>
<p>4.3 Phosphate Glass Structure 46</p>
<p>4.4 Temperature Behaviour and Crystallisation 50</p>
<p>4.5 Phosphate Glass Dissolution 56</p>
<p>4.6 Cell Compatibility of Glasses 59</p>
<p>4.7 Phosphate Glass Fibres and Composites 60</p>
<p>4.8 Applications 62</p>
<p>4.9 Summary 63</p>
<p>5 The Structure of Bioactive Glasses and Their Surfaces 67<br /> Alastair N. Cormack</p>
<p>5.1 Structure of Glasses 67</p>
<p>5.2 Structure of Bioactive Glasses 70</p>
<p>5.3 Computer Modeling (Theoretical Simulation) of Bioactive Glasses 71</p>
<p>5.4 Glass Surfaces 74</p>
<p>5.5 Summary 76</p>
<p>6 Bioactive Borate Glasses 77<br /> Steven B. Jung</p>
<p>6.1 Introduction 77</p>
<p>6.2 What Differentiates a Bioactive Borate Glass from Other Bioactive Glasses? 78</p>
<p>6.3 Evaluating Reactive Materials (</p>
<p>6.4 Multifunctional Bioactive Borate Glasses 83</p>
<p>6.5 Applications of Bioactive Borate Glasses in Orthopedics and Dental Regeneration 86</p>
<p>6.6 Soft Tissue Wound Healing 88</p>
<p>6.7 Tissue/Vessel Guidance 92</p>
<p>6.8 Drug Delivery 93</p>
<p>6.9 Commercial Product Design 94</p>
<p>6.10 Summary 96</p>
<p>7 Glass Ceramics 99<br /> Wolfram Holand</p>
<p>7.1 Glass Ceramics and Their Uses 99</p>
<p>7.2 Methods Used for the Controlled Crystallization of Glasses 101</p>
<p>7.3 A Glass Ceramic that Hardly Expands When Heated 103</p>
<p>7.4 High–Strength, Moldable Glass Ceramics for Dental Restoration 104</p>
<p>7.5 Glass Ceramics that are Moldable and Machinable 106</p>
<p>7.6 Outlook 106</p>
<p>8 Bioactive Glass and Glass Ceramic Coatings 109<br /> Enrica Verne</p>
<p>8.1 Introduction 109</p>
<p>8.2 Enameling 110</p>
<p>8.3 Glazing 114</p>
<p>8.4 Plasma Spraying 117</p>
<p>8.5 Radiofrequency Magnetron Sputtering Deposition 119</p>
<p>8.6 Pulsed Laser Deposition 119</p>
<p>8.7 Summary 120</p>
<p>9 Composites Containing Bioactive Glass 123<br /> Aldo R. Boccaccini and Qi–Zhi Chen</p>
<p>9.1 Introduction 123</p>
<p>9.2 Biodegradable Polymers 127</p>
<p>9.3 Composite Scaffolds Containing Bioactive Glass 131</p>
<p>9.4 Processing Technologies for Porous Bioactive Composites 133</p>
<p>9.5 Case Study: the PDLLA Bioglass Composite Scaffold System 138</p>
<p>9.6 Final Remarks 139</p>
<p>10 Inorganic Organic Sol Gel Hybrids 141<br /> Yuki Shirosaki, Akiyoshi Osaka, Kanji Tsuru, and Satoshi Hayakawa</p>
<p>10.1 Introduction 141</p>
<p>10.2 Hybrids in Medicine and Why They Should Be Silica–Based 142</p>
<p>10.3 Self–Assembled Hybrid Films and Layers of Grafted Silanes 145</p>
<p>10.4 Sol Gel Hybrids 146</p>
<p>10.5 Ormosils 148</p>
<p>10.6 Polymer Choice and Property Control in Hybrids 151</p>
<p>10.7 Maintaining Bioactivity in Sol Gel Hybrids 154</p>
<p>10.8 Summary and Outlook 158</p>
<p>11 Dental Applications of Glasses 161<br /> Leena Hupa and Antti Yli–Urpo</p>
<p>11.1 Introduction 161</p>
<p>11.2 Structure of the Human Tooth 162</p>
<p>11.3 Glass Bioactivity and Teeth 163</p>
<p>11.4 Bioactive Glass in Dental Bone Regeneration 166</p>
<p>11.5 Treatment of Hypersensitive Teeth 168</p>
<p>11.6 Bioactive Glass Coating on Metal Implants 169</p>
<p>11.7 Antimicrobial Properties of Bioactive Glasses 172</p>
<p>11.8 Bioactive Glasses in Polymer Composites 173</p>
<p>11.9 Bioactive Glasses in Glass Ionomer Cements 174</p>
<p>11.10 Summary 175</p>
<p>12 Bioactive Glass as Synthetic Bone Grafts and Scaffolds for Tissue Engineering 179<br /> Julian R. Jones</p>
<p>12.1 Introduction 179</p>
<p>12.2 Synthetic Bone Grafts and Regenerative Medicine 181</p>
<p>12.3 Design Criteria for an Ideal Synthetic Bone Graft 183</p>
<p>12.4 Bioglass and the Complication of Crystallisation During Sintering 184</p>
<p>12.5 Making Porous Glasses 185</p>
<p>12.6 The Future: Porous Hybrids 196</p>
<p>12.7 Bioactive Glasses and Tissue Engineering 200</p>
<p>12.8 Regulatory Issues 201</p>
<p>12.9 Summary 202</p>
<p>13 Glasses for Radiotherapy 205<br /> Delbert E. Day</p>
<p>13.1 Introduction 205</p>
<p>13.2 Glass Design and Synthesis 208</p>
<p>13.3 Non–Degradable or Bio–inert Glasses: Rare Earth Aluminosilicate Glasses 208</p>
<p>13.4 Biodegradable Glasses: Rare Earth Borate/Borosilicate Glasses 211</p>
<p>13.5 Design of Radioactive Glass Microspheres for In Vivo Applications 213</p>
<p>13.6 Treatment of Liver Cancer: Hepatocellular Carcinoma 217</p>
<p>13.7 Treatment of Kidney Cancer: Renal Cellarcinoma 222</p>
<p>13.8 Treatment of Rheumatoid Arthritis: RadiationSynovectomy 223</p>
<p>13.9 Summary 227</p>
<p>References 228</p>
<p>Index 231</p>