Foreword Cathy Wilfert; List of contributors; Preface; Introduction; Part I. Scientific Basis of Pediatric HIV Care: 1. Normal development and physiology of the immune system Sherlyn Smith and Ann J. Melvin; 2. HIV basic virology for clinicians Steven L. Zeichner; 3. The immunology of pediatric HIV disease Elizabeth J. McFarland; 4. The clinical virology of pediatric HIV disease Paul Palumbo; 5. The natural history of pediatric HIV disease Grace M. Aldrovandi; 6. Epidemiology of pediatric HIV disease Mary Lou Lindegren; Part II. General Issues in the Care of Pediatric HIV Patients: 7. Diagnosis of HIV infection in children Paul Krogstad; 8. Prevention of mother-to-child transmission of HIV Jennifer S. Read; 9. Routine pediatric care Elaine Abrams and Lisa-Gaye Robinson; 10. Immunizations Rachel Y. Moon; 11. Prevention of opportunistic infections and other infectious complications of HIV in children Russell B. Van Dyke; 12. Emergency evaluation and care James M. Callahan; 13. Adherence to antiretroviral therapy in children and youth John Farley; 14. Adolescents and HIV Bret R. Rudy; 15. Adolescent reproductive health and HIV Ligia Peralta and Sandra Cely; 16. Growth, nutrition and metabolism Caroline J. Chantry and Jack Moye Jr; 17. Neurobehavioral function and assessment of children with and adolescents with HIV-1 infection Pamela L. Wolters and Pim Brouwers; Part III. Antiretroviral Therapy: 18. Antiretroviral therapy Ross McKinney Jr; 19. Antiretroviral drug interactions Thomas N. Kakuda and Courtney V. Fletcher; 20. Metabolic complications of antiretroviral therapy in children Carol J. Worrell; 21. HIV drug resistance Frank Maldarelli; 22. Initiating and changing antiretroviral therapy Lynne M. Mofenson and Leslie K. Serchuck; 23. Therapeutic drug monitoring Stephen C. Piscitelli; 24. HIV post-exposure prophylaxis for pediatric patients Kenneth L. Dominguez; Part IV. Clinical Manifestations of HIV Infection in Children: 25. Cutaneous diseases Andrew Blauvelt; 26. Neurologic problems Lucy Civitello; 27. Ophthalmologic problems Howard F. Fine, Susan S. Lee and Michael R. Robinson; 28. Oral health and dental problems Jane C. Atkinson; 29. Otitis media and sinusitis Ellen R. Wald and Barry Dashefsky; 30. Cardiac problems Gul H. Dadlani and Steven E. Lipshultz; 31. Pulmonary problems Lauren V. Wood; 32. Hematologic problems William C. Owen and Eric J. Werner; 33. Gastrointestinal disorders Harland S. Winter and Jack Moye; 34 Renal disease associated with pediatric HIV infection Somsak Tanawattanacharoen and Jeffrey B. Kopp; 35. Endocrine disorders Daina Dreimane and Mitchell E. Geffner; 36. Neoplastic disease in pediatric HIV infection Richard F. Little; Part V. Infectious Problems in Pediatric HIV Disease: 37. Serious infections caused by typical bacteria Shirley Jankelevich; 38. Tuberculosis Rohan Hazra; 39. Disseminated Mycobacterium avium complex infection Robert N. Husson; 40 Fungal infections Corina E. Gonzalez; 41. Herpesvirus infections Richard M. Rutstein and Stuart E. Starr; 42. Pneumocystis carinii (PCP) Leslie K. Serchuck; Part VI. Medical Social and Legal Issues: 43. Clinical trials for HIV infected children James McNamara; 44 Medical issues related to the care for HIV-infected children in the home, day care, school, and community Stephen J. Chanock; 45. Contact with social service agencies Sandra Y. Lewis and Heidi J. Haiken; 46. Disclosure Lori S. Wiener; 47. Bereavement Lori S. Wiener; 48. Legal issues for HIV-infected children Carolyn McAllaster; Appendices; Formulary: antiretroviral agents Paul Jarosinki; Formulary: drugs for opportunistic infections associated with HIV Paul Jarosinki; NIH-sponsored clinical trials for pediatric HIV disease James G. McNamara; Selected HIV-related Internet resources Leslie K. Serchuck; Selected legal resources for HIV-infected children Carolyn McAllaster; Index.