Foreword H. Franklin Bunn; Preface; Introduction David Weatherall; Part I. The Cellular, Molecular and Genetic Basis of Hemoglobin Disorders: Introduction; 1. The development of hematopoiesis Elaine Dzierzak; 2. Erythropoiesis S. Philipsen and W. G. Wood; 3. The normal structure regulation of human globin gene clusters Bernard G. Forget and Ross C. Hardison; 4. The normal regulation of globin gene expression Gerd A. Blobel and Mitchell J. Weiss; 5. The molecular and cellular basis of developmental globin gene switching George Stamatoyannopoulos; 6. Structure and function of hemoglobin and its dysfunction in sickle cell disease Daniel Kim-Shapiro; 7. Hemoglobins of the embryo, fetus and adult Martin H. Steinberg and Ronald L. Nagel; Part II. Pathophysiology of Hemoglobin and its Disorders: Introduction; 8. Vascular biology Dhananjat Kaul; 9. The erythrocyte membrane Clint Joiner and Patrick Gallagher; 10. The biology of vascular nitric oxide Jane A. Leopold and Joseph Loscalzo; 11. Mechanisms and complications of hemolysis in sickle cell disease and thalassemia Gregory J. Kato and Mark T. Gladwin; 12. The importance of animal models in understanding pathophysiology Mary Fabry; Part III. α Thalassemia: Introduction: 13. The molecular basis of alpha thalassemia Douglas R. Higgs and Vip Viprakasit; 14. The pathophysiology and clinical features of alpha thalassemia Douglas R. Higgs, Vip Viprakasit and Don Bowden; 15. Alpha thalassemia with mental retardation and myelodysplasia Douglas R. Higgs, Richard Gibbons, and David Steensma; Part IV. Beta Thalassemia: Introduction: 16. The molecular basis of beta thalassemia S. L. Thein and W. G. Wood; 17. Clinical aspects of beta thalassemia and related disorders Nancy F. Olivieri, D. K. Bowden, and D. J. Weatherall; 18. HbE disorders Suthat Fuchareon and David Weatherall; Part V. Sickle Cell Disease: Introduction: 19. Clinical and pathophysiological aspects of sickle cell anemia Martin Steinberg, Kwaku Ohene-Frempong, and Matthew M. Heeney; 20. Biology of pain and treatment of the sickle cell painful episode Samir K. Ballas and James R. Eckman; 21. HbSC disease and HbC Martin H. Steinberg and Ronald L. Nagel; 22. Sickle cell trait Martin H. Steinberg; 23. Other sickle hemoglobinopathies Martin H. Steinberg; Part VI. Other Clinically Important Disorders of Hemoglobin: Introduction: 24. Unstable hemoglobins; hemoglobins with altered oxygen affinity; hemoglobin M; other variants of clinical and biological interest Martin H. Steinberg and Ronald L. Nagel; 25. Dyshemoglobinemias Neeraj Agarwal and Ronald L. Nagel; Part VII. Special Topics in Hemoglobinopathies: Introduction: 26. Population genetics and global health burden David J. Weatherall and Thomas N. Williams; 27. Genetic modulation of sickle cell disease and thalassemia Martin H. Steinberg and Ronald L. Nagel; 28. Developments in laboratory methods to detect hemoglobinopathies Mary Fabry and John M. Old; Part VIII. New Approaches to the Treatment of Hemoglobinopathies and Thalassemia: Introduction: 29. Transfusion and iron chelation John Porter, Alan R. Cohen and Janet L. Kwiatkowski; 30. Induction of HbF Yogen Saunthararajah and George F. Atweh; 31. Novel approaches to treatment - (anitoxidants, statins, anti-inflammatory agents, K-Cl and Gardos inhibitors, other transport inhibitors, NO) Carlo Brugnara, Kirkwood A. Pritchard, Jr and Cheryl Hillery; 32. Stem cell transplantation Emanuele Angelucci and Mark Walters; 33. Gene therapy Derek A. Persons, Brian P. Sorrentino, and Arthur W. Nienhuis.
