Preface; 1. Scope and implications of MRI-negative refractory focal epilepsy Elson L. So and Philippe Ryvlin; 2. Seizure semiology and scalp EEG in MRI-negative refractory focal epilepsy Soheyl Noachtar and Elisabeth Hartl; 3. Clinical and advanced techniques for optimizing MRI in refractory focal epilepsy Neda Bernasconi and Andrea Bernasconi; 4. PET in MRI-negative refractory focal epilepsy Alexander Hammers; 5. Advanced SPECT image-processing in MRI-negative refractory focal epilepsy Elson L. So, Terence J. O'Brien and Benjamin H. Brinkmann; 6. MEG and magnetic source imaging in MRI-negative refractory focal epilepsy Koji Iida, Akira Hashizume and Hiroshi Otsubo; 7. Electric source imaging in MRI-negative refractory focal epilepsy Christoph M. Michel and Margitta Seeck; 8. Functional MRI in MRI-negative refractory focal epilepsy Friederike Möller and Stephan Ulmer; 9. Multimodality image co-registration for MRI-negative epilepsy surgery Benjamin H. Brinkmann and Vlastimil Sulc; 10. Subdural electrode implantation and recording in MRI-negative epilepsy surgery Michael R. Sperling and Christopher T. Skidmore; 11. Depth electrode and stereoelectroencephalography in MRI-negative epilepsy Philippe Ryvlin, Alexandra Montavont, Karine Ostrowsky-Coste and Marc Guénot; 12. Ultraslow and high-frequency recordings in MRI-negative refractory focal epilepsy Vlastimil Sulc and Gregory A. Worrell; 13. Cortical mapping in MRI-negative epilepsy surgery Gonzalo Alarcón and Antonio Valentín; 14. Localization and surgery for MRI-negative temporal lobe and temporal-plus epilepsies Sang Kun Lee and Hyejin Moon; 15. Localization and surgery in MRI-negative frontal lobe epilepsies Chathurbhuj Rathore and Kurapath Radhakrishnan; 16. Localization and surgery in MRI-negative posterior cortical epilepsies Christoph Baumgartner and Susanne Pirker; 17. MRI-negative refractory focal epilepsy in childhood Prasanna Jayakar and Michael Duchowny; 18. Surgical approaches and techniques in MRI-negative focal epilepsy Sumeet Vadera and William Bingaman; 19. Histopathology findings in MRI-negative focal epilepsy Ingmar Blümcke and Roland Coras; 20. Neuropsychological issues in MRI-negative focal epilepsy surgery: evaluation and outcomes Rosana Esteller, Daniel L. Drane, Kimford J. Meador and David W. Loring; 21. Conclusion Philippe Ryvlin and Elson L. So; Index.