Preface; Foreword Joseph J. Volpe; Part I. Scientific Background: 1. Neurological outcome after perinatal asphyxia at term David Odd and Andrew Whitelaw; 2. Molecular mechanisms of neonatal brain injury and neural rescue Pierre Gressens and Henrik Hagberg; 3. The discovery of hypothermic neural rescue therapy for perinatal hypoxic-ischaemic encephalopathy A. David Edwards; 4. Clinical trials of hypothermic neural rescue A. David Edwards and Denis V. Azzopardi; 5. Economic evaluation of hypothermic neural rescue Dean A. Regier and Stavros Petrou; Part II. Clinical Neural Rescue: 6. Challenges for parents and clinicians discussing neuroprotective treatments Peter Allmark, Claire Snowdon, Diana Elbourne and Su Mason; 7. The pharmacology of hypothermia Alistair J. Gunn and Paul P. Drury; 8. Selection of infants for hypothermic neural rescue Ericalyn Kasdorf and Jeffrey M. Perlman; 9. Hypothermia during patient transport Susan E. Jacobs; 10. Whole body cooling for therapeutic hypothermia Abbot R. Laptook; 11. Selective head cooling Paul P. Drury, Laura Bennet and Alistair J. Gunn; 12. Hypothermic neural rescue for neonatal encephalopathy in mid- and low-resource settings Nicola J. Robertson and Sudhin Thayyil; 13. Cerebral function monitoring and EEG Lena Hellström-Westas; 14. Magnetic resonance imaging in hypoxic-ischaemic encephalopathy and the effects of hypothermia Mary A. Rutherford and Serena Counsell; 15. Novel uses of hypothermia Seetha Shankaran and Rosemary Higgins; 16. Neurological follow-up of infants treated with hypothermia Charlene M. T. Robertson and Joe M. Watt; 17. Registry surveillance after neuroprotective treatment Jeffrey D. Horbar, Robert H. Pfister and Denis V. Azzopardi; Part III. The Future: 18. Novel neuroprotective therapies Sandra E. Juul, Donna M. Ferriero and Mervyn Maze; 19. Combining hypothermia with other therapies for neonatal neuroprotection Faye S. Silverstein and John D. Barks; 20. Biomarkers for studies of neuroprotection in infants with hypoxic ischaemic encephalopathy Denis V. Azzopardi and A. David Edwards; Index.
