Mathematical Models and Immune Cell Biology

Preface.- Thymocyte development.- A review of mathematical models for T cell receptor triggering and antigen discrimination.- Dynamic tuning of T cell receptor specificity by co-receptors and costimulation.- T cell activation and function: role of signal strength.- The cyton model for lymphocyte proliferation and differentiation.- Modeling itravital two-photon data of lymphocyte migration and interaction.- Modeling lymphocyte dynamics in vivo.- Continuous-time birth and death processes: diversity maintenance of naïve T cells in the periphery.- Multivariate competition processes: a model for two competing T cell clonotypes.- Stochastic modeling of T Cell homeostasis for two competing clonotypes via the master equation.- Dendritic cell migration in the intestinal tract.- Reassessing germinal center reaction concepts.- B cell strategies of Ag recognition in a stratified immune system.- Dynamics of Peripheral regulatory and effector T cells competing for antigen presenting cells.- Mathematical models of the role of IL-2 in the interactions between helper and regulstory CD4+ T cells.- A Physicist’s approach to immunology.- Timescales of the adaptive immune response.- Using mathematical models to explore the role of cytoxic T lymphocytes in HIV infection.- Viral immunity and persistence.- Index.