Jingwu Xie
Springer New York
2011e druk, 2011
9781441984340
Hedgehog signaling activation in human cancer and its clinical implications
Specificaties
Gebonden, 217 blz.
|
Engels
Springer New York |
2011e druk, 2011
ISBN13: 9781441984340
Rubricering
Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Specificaties
ISBN13:9781441984340
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:217
Uitgever:Springer New York
Druk:2011
Inhoudsopgave
<p>Chapter 1- Overview of hedgehog signaling pathway</p><p>Chi-chung Hui<sup> </sup>and<sup> </sup>Jin Jiang</p><p> </p><p>Chapter 2- Regulation of Hh morphogene gradient</p><p>G. D’Angelo, F. Wendler, K. Ayers and P.P. Thérond<sup></p><p> </p><p>Chapter 3- Smoothened Signaling through a G-protein Effector Network</p><p>David J. Robbins and Stacey K. Ogden</p><p> </p><p>Chapter 4- Kinases and phosphatases in hedgehog signaling</p><p>Jianhang Jia</p><p> </p><p>Chapter 5- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer</p><p>Xiaodong Cheng</p><p> </p><p>Chapter 6- Crosstalks between PKC and hedgehog signaling</p><p>Jing Li and Mark Evers</p><p> </p><p>Chapter 7- Activation of Hh signaling in human cancer</p><p>Jingwu Xie and Ervin Epstein</p><p> </p><p> Chapter 8- Hedgehog signaling in pediatric brain tumors</p><p>Joon Won Yoon, Ph.D., Jason Fangusaro, M.D., Philip Iannaccone, M.D., Ph.D., and David Walterhouse, M.D.</p><p> </p><p>Chapter 9- Hedgehog Signaling in Mammary Gland Development and Breast Cancer</p><p>Adriana P. Visbal<sup> </sup>and Michael T. Lewis<sup></p><p> </p><p>Chapter 10- Hedgehog signaling and cancer therapeutic resistance </p><p>K.S. Clifford Chao and Yu-Jen Chen </p><p> </p><p>Chapter 11- Small-molecule Inhibitors of the Hedgehog Pathway</p><p>Ari J. Firestone and James K. Chen<sup></p><p> </p><p>Chapter 12- Cyclopamine and its derivatives for cancer therapeutics</p><p>Martin Tremblay and Karen McGovern</p>