Gene Therapy of Cancer

Tumor Biology.- 1. Expression Genetics in Cancer Research, Prognosis, and Therapy.- 2. Patterns of Chromosomal Imbalances in Carcinomas of the Respiratory Tract.- 3. Inhibition of Tumorigenesis in a Murine B-Cell Lymphoma Transplant Model by c-Myc Complementary Oligonucleotides.- 4. Telomerase Inhibition by Induced Expression of Antisense RNA.- 5. Ex Vivo and in Vivo IGF-I Antisense RNA Strategies for Treatment of Cancer in Humans.- 6. Use of the IGF-I Antisense Strategy in the Treatment of the Hepatocarcinoma.- 7. Functional Involvement of CD44, a Family of Cell Adhesion Molecules, in Immune Responses, Tumour Progression and Haematopoiesis.- 8. The Influence of CD44 Splice Variants to the Outcome of Patients with Oral Squamous Cell Carcinoma.- 9. Control of Tumor Growth via Inhibition of Tumor Angiogenesis.- 10. Expression of Collagenase-3 (MMP-13) by Tumor Cells in Squamous Cell Carcinomas of the Head and Neck.- 11. High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achieved by Adenovirus Mediated Gene Transfer.- 12. Tissue Inhibitor of Metalloproteinase Expression: A Target for Gene Therapy in Renal Cell Carcinoma.- 13. In Vivo Tumor Suppressor Effect of Retrovirus-Mediated Gene Transfer of the Adenovirus E1a Gene.- 14. Antitumor Effect of E1B Defective Adenoviruses in Human Malignant Cells.- 15. Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Growth Suppressing Gene, tob, in Vitro.- Chemogene Therapy.- 16. Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy.- 17. Sensitisation of Human Ovarian Cancer Cells to Killing by the Prodrug CB1954 Following Retroviral or Adenoviral Transfer of the E. coli Nitroreductase Gene.- 18. HSV-1 Thymidine Kinase Gene Therapy for Peritoneal Carcinomatosis.- 19. Characteristics of Cytosine Deaminase-5-Fluorocytosine System: Enhancement of Radiation Cytotoxicity and Bystander Effect.- 20. Potentiation of the Bystander Effect by Immunization Combined with Suicide Gene Therapy.- 21. Another Mechanism Causing the Bystander Effect Besides the Gap Junction’s Role during the Glioma Gene Therapy with HSV-TK/GCV System.- 22. In Vivo Evaluation of a Drug-Inducible Vector System for the Combined Gene- and Chemotherapy of Cancer.- 23. IL-2 Gene Transfer for Chemosensitization of Multidrug-Resistant Human Colon Carcinoma Cells.- 24. Cytotoxic Effect of Binar Cisplatin Immunoconjugate.- 25. Dietary Indole Derivatives Induce Apoptosis in Human Breast Cancer Cells.- Tumor Immunology.- 26. Overcoming T Cell Ignorance by Providing Costimulation: Implications for the Immune Response against Cancer.- 27. Immune Cells in the Tumor Microenvironment: Mechanisms Responsible for Functional and Signaling Defects.- 28. Dendritic Cells Prevent CD95 Mediated T Lymphocyte Death through Costimulatory Signals.- 29. Interleukin-10 Inhibits the Immune Stimulatory Potential of Melanoma Cells Retrovirally Transduced with Human B7.1 or B7.2.- 30. Immunosuppressive Cells in Bone Marrow of Patients with Stomach Cancer.- 31. Induction of Antigen-Specific T Cells by Allogeneic CD80 Transfected Human Carcinoma Cells.- 32. IL-12-Activated NK Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells.- 33. Effects of Altered Antigen Processing on T-Cell Responses toward Murine T-Lymphomas.- 34. Cancer Gene Therapy with a Heat Shock Protein Gene.- 35. Heat Shock Protein (HSP72) Surface Expression Enhances the Lysis of a Human Renal Cell Carcinoma by IL-2 Stimulated NK Cells.- 36. Identification of Epitopes for CTCL-Specific Cytotoxic T Lymphocytes.- 37. Effects of Altered Antigen Processing on H-2Dk Mediated NK Inhibition in a Murine T Lymphoma Model.- 38. Recognition of Melanoma-Associated Peptides by Peripheral Blood Mononuclear Cells of Ocular Melanoma Patients.- 39. Detection of Micrometastasis in 31 Patients with Breast Cancer by RT-PCR and Immunomagnetic Separation (ISM) Techniques.- Immunogene Therapy.- 40. Human Tumor Immunotherapy: New Opportunities as Well as New Challenges.- 41. Modification of Cancer Vaccines by Virus Infection and Attachment of Bispecific Antibodies: An Effective Alternative to Somatic Gene Therapy.- 42. Immunotherapy of Established Tumor with MHC Class II and B7.1 Cell-Based Tumor Vaccines.- 43. Retroviral B7.1 Gene Transfer in Cancer Cells Protects Cytotoxic T Cells from Deletion by “Veto” Apoptosis.- 44. Hybrid Cell Vaccination in Cancer Immunotherapy: Recruitment and Activation of T Cell Help for Induction of Anti Tumour Cytotoxic T Cells.- 45. Treatment of Hepatocellular Carcinoma with the Cellular Tumor Vaccines Generated by in Vitro Modification of Tumor Cells with Non Gene Transfer Approaches.- 46. DNA Vaccines Targeting Dendritic Cells for the Immunotherapy of Cancer.- 47. A DNA Vaccine against Malignant Melanoma Coexpressing Antigen and Cytokine.- 48. DNA Immunization in Mice against Virus-Induced Tumor Antigens.- 49. IL-4 Gene Transfer for the Treatment of Experimental Gliomas.- 50. Strategies to Elicit Anti-Idiotypic Immune Response in B-Lymphoma Patients: Peptide and Genetic Immunization.- 51. Autologous Fibroblasts as Potential Vehicle for Regional Ovarian Cancer Gene Therapy.- 52. Adenovirus-Mediated ex Vivo Immunogene and in Vivo Combination Gene Therapy Strategies Induce a Systemic Anti-Tumor Immune Defense in the Mouse B16 Melanoma Model.- 53. Stable Expression of a Retrovirally Transferred Adhesion Molecule in a Human Tumor-Specific CTL Clone: Perspectives for the ex Vivo Manipulation of Effector Cells Used in Adoptive Immunotherapy.- 54. ?-Interferon Gene Transfer as a Therapeutic Strategy for Ovarian Cancer.- 55. Enhancement of Anti-Tumor Immunity by Injection of Fibroblasts Genetically Engineered to Produce IL-12 and to Express CD70.- 56. Sensitization of Human Cells to Lysis by Human Complement as an Approach for Cancer Gene Therapy.- Gene Technology and Gene Targeting.- 57. Targeted Adenoviral Vectors for Cancer Gene Therapy.- 58. High-Efficiency Retroviral Vector-Mediated Gene Transfer into Human T Lymphocytes.- 59. Disabled Infectious Single Cycle (DISC) Herpes Simplex Virus as a Vector for Immunotherapy of Cancer.- 60. Gene Therapy for Familial Adenomatous Polyposis: Prolonged Expression of the Adenomatous Polyposis Coli Gene after Lipofection into Mouse Colon in Vivo.- 61. A Chimeric Fusion Protein of Cytochrome CYP4B1 and Green Fluorescent Protein for Detection of Pro-Drug Activating Gene Delivery and for Gene Therapy in Malignant Glioma.- 62. Toward Targeted Killing of Tumor-Specific Antigen-Producing Cancer Cells by Retrovirus Displaying a Single Chain Variable Fragment Antibody.- 63. A Tool for Enhancing Site-Specific Gene Integration in Mammalian Cells.- 64. Viral Particles with Heterologous Binding Motifs: An Approach to Specifically Alter the Tropism of the B-Lymphotropic Papovavirus.- 65. Efficient Retroviral Infection of Human Cells Utilising an Adenoviral Vector Expressing the Ecotropic Receptor.- 66. Monoclonal Antibody 138H11 against Gamma-Glutamyltransferase Provides a Possible Tool for Targeting Calicheamicin ? to Renal Cell Carcinomas.- 67. Cell Cycle Regulated Promoters for the Targeting of Tumor Endothelium.- 68. Development of a Double-Copy Bicistronic Retroviral Vector for Human Gene Therapy.- 69. Gene-Modified Dendritic Cells by Receptor-Mediated Transfection.- 70. Simple and Fast Microscale Procedure for Transfection and Quantification of Reporter Gene Expression in Eukaryotic Cells.- 71. A Novel Series of Serum-Resistant Lipoaminoacid Compounds for Cellular Delivery of Plasmid DNA.- 72. Comparison of Antisense Vectors and Antisense Oligonucleotides Delivered by Means of the New Cationic Lipids Unifectin and Maxifectin.- 73. Fast-Sorting System for Cells with High-Copy-Number Expression Vectors and Its Use for the Modulation of CML Cells.- 74. Plasmid DNA for Clinical Phase I and II Studies: Large-Scale cGMP Manufacturing and Quality Assurance.- 75. Large Scale Purification of Plasmid DNA for Use in Gene Therapy.- Clinical Trials.- 76. Gene Marking and Gene Therapy in Multiple Myeloma.- 77. p53 and Gene Therapy for Hepatocellular Carcinoma.- 78. Gene Therapy for Malignant Glioma Patients.- 79. Immunization of Metastatic Breast Cancer Patients with CD80-Modified Breast Cancer Cells and GM-CSF.- 80. A Phase I Trial with a Hybrid Cell Vaccine in Patients with Metastatic Melanoma.- 81. Gene Therapy with AdV-IL2 (TG 1021) in Unresectable Digestive Adenocarcinoma: Phase I–II Study, First Inclusions.- 82. Gene Therapy with Cytokine-Transfected Xenogeneic Cells in Metastatic Tumors.- 83. Application of Gene Transfer in Cancer Immunotherapy: From Experimental Data to Clinical Protocols.- 84. Active Immunization of Metastatic Melanoma Patients with IL-2 or IL-4 Gene Transfected, Allogeneic Melanoma Cells.- 85. Preparation for a Phase I/II Study Using Autologous Gene Modified T Lymphocytes for Treatment of Metastatic Renal Cancer Patients.- 86. Immunogene Therapy of Human Melanoma: Phase I/II Clinical Trial.