Adam R. Karpf
Springer New York
2013e druk, 2014
9781489985583
Epigenetic Alterations in Oncogenesis
Specificaties
Paperback, 348 blz.
|
Engels
Springer New York |
2013e druk, 2014
ISBN13: 9781489985583
Rubricering
Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.
Specificaties
ISBN13:9781489985583
Taal:Engels
Bindwijze:paperback
Aantal pagina's:348
Uitgever:Springer New York
Druk:2013
Inhoudsopgave
<p>Preface.- Section I: Epigenetic Marks and Mechanisms.- DNA methyltransferases (DNMTs), DNA damage repair, and cancer.- DNA hypomethylation and hemimethylation in cancer.- Ten Eleven Translocation (TET) Enzymes and 5-hydroxymethylation in Mammalian Development and Cancer.- Altered histone modifications in cancer.- Nucleosome occupancy and gene regulation during tumorigenesis.- Section II: The Impact of Epigenetic Alterations on Cancer Biology.- Epigenetic regulation of miRNAs in cancer.- DNA hypomethylation and activation of germline-specific genes in cancer.- APC and DNA demethylation in cell fate specification and intestinal cancer.- Epigenetic changes during cell transformation.- Epigenetic reprogramming of mesenchymal stem cells.- Section III: Clinical Implications and Analysis Methods.- Environmental toxicants, epigenetics, and cancer.- Blood derived DNA methylation markers of cancer risk.- Epigenetic therapies in MDS and AML.- Epigenetic targeting therapies to overcome chemotherapy resistance.- Methods for cancer epigenome analysis.- Index</p>