<p>Part I Prelude.- 1 Space Travel: A Personal View from Above.- 2 Prelude: An integrative and up-dated view from the Scientists of the Topical Team “Stress and Immunity”.- Part II “Stress and Immunity” – Research: A Link Between Space and Earth.- 3 What Is Stress?.- 4 The special relation of mitochondria, metabolism and stress.- 5 The Impact of Everyday Stressors on the Immune- System and Health.- Part III Stress and Immune Allostasis in Space, from Brain to Immune Responses.- 6 Neurobiological and Molecular Mechanisms of Stress and Glucocorticoid Effects on Learning and Memory: Implications for Stress Disorders on Earth and in Space.- 7 The Autonomic Nervous System.- 8 Circadian Rhythm and Stress.- 9 Endocannabinoids, “New-Old” Mediators of Stress Homeostasis.- 10 Immune System in Space: General Introduction and Observations on Stress-Sensitive Regulations.- 11 Innate Immunity Under Conditions of Space Flight.- 12 NK Cells Assessments: A Fourty-Year-Old History of Immune Stress Interaction in Space.- 13 Adaptive Immunity and Spaceflight.- 14 B-cell Immunology in Space.- 15 Stress, Hypoxia, and Immune Response.- 16 Gravitational Force: Triggered Stress in Cells of the Immune System.- 17 Microbial Stress: Spaceflight-induced Alterations in Microbial Virulence and Infectious Disease Risks for the Crew.- 18 Stress, Spaceflight, and Latent Herpes Virus Reactivation.- 19 Stress and Radiation-Immune-Responsiveness.- Part IV Preventive and Diagnostic Tool and Strategies.- 20 Considerations for Development and Application of Health Monitoring Tools in Space.- 21 Psychological Monitoring.- 22 Technology up-date for monitoring Autonomic Activity.- 23 Breath Gas Analysis.- 24 Monitoring the Microbial Burden in Manned Space Stations and Analogue environments.- 25 Monitoring of Body Core Temperature in Space.- 26 Flow Cytometry and cryopreservation Methods to Monitor Immune Dysregulation Associated with Spaceflight.- 27 Assessment of Radiosensitivity and Monitoringof Radiation-Induced Cellular Damage.- 28 Hair analyses – growing evidence.- Part V Therapeutic Strategies.- 29 Considerations for Preventive and Therapeutic Strategies.- 30 Psychological Countermeasures.- 31 Physical Countermeasures to Stress.- 32 Nutritional Countermeasures for Spaceflight-Related Stress.- 33 The Microbiome perspective: Immune – gut- axis modulation.- 34 Pharmacological Countermeasures to Spaceflight-Induced Alterations of the Immune System.- Part VI Perspectives for Manned Space Exploration – from Visions to Realities.- 35 Platforms for Stress and Immune Research in Preparation of Long-Duration Space Exploration Missions.- 36 MARS500 the first preparation of Long-Duration Space Exploration Missions - lessons learned for space exploration and health on Earth.- 37 On the ICE: Isolated, Confined and Extreme Environment.- 39 Moon, Mars and Beyond- the exploration roadmap and further visions. </p><p> </p><p> </p>
