Present Basis of Coronary Therapy.- Session I. Chemistry and Experimental Pharmacology.- Pharmacology of Nifedipine.- Discussion Remarks.- The Chemistry of Nifedipine.- Pharmacokinetics of Adalat in Animal Experiments.- Investigations on the Metabolism and Protein Binding of Nifedipine.- Discussion Remarks.- Experimental Pharmacological Investigations of Effects of Nifedipine on Atrioventricular Conduction in Comparison with Those of Other Coronary Vasodilators.- Discussion Remarks.- Studies on the Extracardial Effects of Nifedipine in Anesthetized Dogs.- Discussion Remarks.- Session II. Experimental Pharmacology.- Adalat, a Powerful Ca-Antagonistic Drug.- Ca-Dependent Changes in Coronary Smooth Muscle Tone and the Action of Ca-Antagonistic Compounds with Special Reference to Adalat.- Discussion Remarks.- Myocardial Oxygen Consumption under the Influence of Nifedipine (Adalat) in the Anesthetized Dog.- Discussion Remarks.- Hemodynamic Effects of Adalat in the Unanesthetized Dog.- Discussion Remarks.- Investigations on the Development of Collaterals, Coronary Flow, Tachyphylaxis and Steal Phenomenon in Dogs after Application of Adalat.- The Effect of Adalat on the Mechanical and Electrical Activity of Isolated Rat Cardiac Muscle, with Special Reference to Calcium Antagonism of the Compound.- Discussion Remarks.- Session III. Clinical Pharmacology.- Hemodynamic Studies on Adalat in Healthy Volunteers and in Patients.- Discussion Remarks.- Pharmacokinetics of Nifedipine-14C in Man.- Hemodynamic Studies on the New Coronary Therapeutic Drug Nifedipine (BAY a 1040).- Discussion Remarks.- Effect of Nifedipine (Adalat) on Myocardial Oxygen Extraction and Lactate Metabolism and ST-T Segment Changes in Patients with Coronary Insufficiency during Artificial Stimulation of the Heart.- Hemodynamic Effect of Nifedipine (Adalat) in Patients Catheterized for Coronary Artery Disease.- Discussion Remarks.- Session IV. Clinical Pharmacological Efficacy.- Comparison of the Effects of Adalat with Other Substances on the Myocardial Ischemia under Loading Conditions.- Discussion Remarks.- Left Ventricular Hemodynamics in Patients at Rest before and after Nifedipine (Adalat).- Discussion Remarks.- Adalat and Beta Blockers; the Mechanism Studied with Two Series of Work Tests in Two Groups of Patients with Angina Pectoris.- Adalat (Nifedipine) under Loading Conditions.- Discussion Remarks.- Results of a Comparative Study with Adalat: Phonomechano-Cardiograms in Normal Persons and Patients with Coronary Heart Disease.- Myocardial Circulation under Adalat in Different Phases of Coronary Diseases.- Discussion Remarks.- Session V. Clinical Aspects: Hemodynamics, Onset and Duration.- Coronary and Left Ventricular Dynamics under Nifedipine in Comparison to Nitrates, Beta-Blocking Agents and Dipyridamole.- Effect of Adalat (Nifedipine) on Left Ventricular Hemodynamics in Angina Pectoris (Comparative Study with Propranolol).- Discussion Remarks.- The Effect of Adalat on Coronary Circulation after Sublingual Administration.- Loading Tolerance after Adalat and Duration of Effect in Postmyocardial Infarction Studied in a Double-Blind Trial.- The Cardiopulmonary Loading Capacity in Healthy Persons and Patients with Coronary Heart Disease after Application of Adalat.- Remarks on Changes of ST Segment Depression during the Day.- Discussion Remarks.- Hemodynamic Study of Nifedipine Using Doppler Flowmetry.- Session VI. Clinical Aspects: Special Studies.- Clinical-Therapeutic and Hemodynamic Studies with Adalat, a New Coronary Active Substance.- Influence of Different Doses of Adalat on Angina Pectoris Induced by Exercise.- Discussion Remarks.- Nifedipine in the Treatment of Ischemic Heart Disease.- Clinical Observations on the Efficacy of Adalat Compared with a Pentaerythrityl Tetranitrate Preparation.- Discussion Remarks.- Clinical Studies on the Combined Effect of Various Antihypertensive Agents and Adalat.- Discussion Remarks.- Response of Intraocular Pressure in Normal Subjects and Glaucoma Patients to Single and Repeated Doses of the Coronary Drug Adalat.- Extracardial Effects of Nifedipine (Adalat): Measurements of Liver Blood Flow in Animals and Humans and of Peripheral Circulation in the Lower Limbs.- Discussion Remarks.- The Influence of Adalat on Pulmonary Pressure.- Comparison of the Effect of Adalat and Propranolol on Exercise Tolerance in Patients with Angina Pectoris.- Session VII. Clinical Aspects: Proof of Clinical Efficacy.- Nifedipine in Angina Pectoris: A Multicentric Clinical Trial.- Discussion Remarks.- An Interim Report on a Cooperative Double-Blind Clinical Trial with Nifedipine.- Discussion Remarks.- Results of a Double-Blind Study with Adalat under Short- and Long-Term Treatment.- Discussion Remarks.- Long-Term Therapy with Adalat. A Preliminary Report.- Discussion Remarks.- Survey and Summary of Results Obtained during the World-Wide Clinical Investigations of Adalat (Nifedipine).- Discussion Remarks.- Closing Remarks.
