Ondansetron and chemotherapy induced emesis

During the 3rd International Congress on Neoadjuvant
Chemotherapy (Paris 1991) a complete symposium was devoted
to chemically induced nausea and vomiting and to the value
of Ondansetron. This book comprises original articles
dealing with the different topics discussed during this
session. It provides fuller information on current practice
in anti-emetic treatment during anti-cancerous chemotherapy
and sets out the position of a new and important drug,
ondansetron, in this pathology. Different international
clinical studies made with ondansetron in various types of
patients are analysed: specific studies in hematology or in
pulmonary disease, evaluation against benzamide-corticoid as
a combined reference standard, or further the additive
effect of a corticoid combined with ondansetron. One article
is devoted to the use of the drug in children. Finally,
recent programmes dealing with both the intravenous and the
oral use of ondansetron are assessed. The last article deals
with the economic evaluation of the use of ondansetron. Thus
the reader will findhere a recent and uo-to-date review of
the results and possible uses of ondansetron, now the
premier member of the class of 5 HT 3 antagonists, in
chemically induced nausea and vomiting.