Molecular Aspects of Oxidative Drug Metabolizing Enzymes

to Cytochrome P450.- General Aspects of NADPH Cytochrome P450 Reductase and Cytochrome b5.- Interaction Between Cytochrome P450 and Reductase.- Molecular Biology of Cytochrome P450: Evolution, Structure and Regulation.- The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators.- Mapping Determinants of the Substrate Specificities of P450s by Site-Directed Mutagenesis.- Diversity and Regulation of Cytochromes P450 in Aquatic Species.- Cytochrome P450 Expression in Rainbow Trout: An Overview.- Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity.- Problems Associated with Assessment of the Contribution of Individual Forms of Cytochrome P450 to the Metabolism of Xenobiotics.- Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function.- Flavin-Containing Monooxygenases: Substrate Specificity and Complex Metabolic Pathways.- Developmental Regulation of Biotransformation of Drugs and Other Xenobiotics.- Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical.- Mechanisms of Mutagenicity and Tumour Formation.- Genotoxicity Assays.- Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals.- Significance of Posttranslational Modification of Drug Metabolizing Enzymes by Phosphorylation for the Control of Carcinogenic Metabolites.- The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics.- In Vitro Systems as Analytical Tools for Understanding and Predicting Drug Metabolism In Vivo.- The Role of Oxidative Enzymes in the Metabolism and Toxicity of Pesticides.- Metabolism of Xenobiotic Proestrogens and Estrogens by Cytochrome P450.- Metabolism of Antiestrogenic Anti-Cancer Agents by Cytochrome P450 and Flavin-Containing Monooxygenases. Mechanism of Action Involving Metabolites.- Therapeutic Agents and Cytochrome P450.- Drug Metabolism, Lipid Peroxidation and Glutathione.- Health Environment of Altai Territory and Monooxygenase and Conjugating Activities in Placentae of Newborn.- Monooxygenase Measurements as Indicators of Pollution in the Field.- Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea.- Relating Biochemical Responses to “Higher Order” Effects.- List of Invited Contributors.