Immunology of Silicones

Silicon, Silica, Silicones: Chemistry and Degradation.- Silica, Silicon and Silicones … Unraveling the Mystery.- Silicone Degradation Reactions.- Chemical, Physical and Mechanical Analysis of Explanted Breast Implants.- Silicon and Silicone Levels in Patients with Silicone Implants.- Detection of Silicone Migration and Biodegration with NMR.- Serum Silicon Levels are Elevated in Women with Silicone Gel Implants.- Interaction of Silicones with Proteins and Tissues.- The Development of an ELISA Method for the Detection of “Antibodies” to Silicone.- The Adsorption of Proteins on a Polydimethylsiloxane Elastomer (PEP) and Their Antigenic Behavior.- Aspecific Immunoglobin Binding to Hydrophobic Surfaces.- Cytotoxicity and Membrane Damage in vitro by Inclusion Complexes Between ?-cyclodextrin and Siloxanes.- Adjuvancy of Silicones.- Induction of Type-Il Collagen Arthritis in the DA Rat Using Silicone Gel as Adjuvant.- The Adjuvancy of Silicones: Dependency on Compartmentalization.- The Adjuvant Effect of Silicone Gel and Silicone Elastomer Particles in Rats.- Silicone Gel and Octamethylcyclotetrasiloxane Potentiate Antibody Production to Bovine Serum Albumin in Mice.- Macrophages, Polyreactive and Antilipid Antibodies.- Fibrogenic and Other Biological Effects of, Silica.- Macrophages in Host Defense Mechanisms.- Structure and Function of, Natural Antibodies.- Antibodies to, Cholesterol: Biological Implications of Antibodies to Lipids.- T-Cell, NK Cell Responses to Silicones.- Silicone-lnduced, T-cell Proliferation in Mice.- Silicone-induced, Modulation of Natural Killer Cell Activity.- HLA Typing in Women with and, without Silicone Gel-filled Breast Implants.- T Cell-Mediated Immune Response to Silica in Silicone Breast Implant Patients.- Immunohistopathology and T-cell Receptor Gene Expression in Capsules Surrounding Silicone Breast Implants.- Cellular Reactions to Silicone Implants.- Macrophage-Silicone Interactions in Women with Breast Prostheses.- Microscopic Techniques and Histologic Finding in Silicone Mammary Implant Capsules and Regional Paranodal Tissues.- Autoimmune Antibodies.- Antinuclear Antibodies in Apparently Healthy Women with Breast Implants.- Silicone Binding Immunoglobulins in Human Sera. With 6 Figures.- Autoantibodies in Patients with Silicone Implants.- Clinical and Laboratory Features of Patients with Scleroderma and Silicone Implants.- Re-Evaluation of Autoantibodies and Clinical Overview of Silicone-Related Disorders. With 1 Figure.- Development of Scleroderma-like Syndrome in Tsk/+ Mice is not Enhanced by Silicone Administration.- Comparative Epitope Mapping of Antibodies to Collagen in Women with Silicone Breast Implants, Systemic Lupus Erythematosus and Rheumatoid Arthritis.- The Prevalence of Autoantibodies in Symptomatic and Asymptomatic Patients with Breast Implants and Patients with Fibromyalgia.- Monocyte/Macrophage Infiltrates in the Salivary Glands of Women with Silicone Breast Implants.- Novel Anti-Silicone Surface-associated Antigen Antibodies (anti-SSAA(x)) may help Differentiate Symptomatic Patients with Silicone Breast Implants from Patients with Classical Rheumatological Disease.- Laboratory Studies in Breast Implant Patients: ANA Positivity Gammaglobulin Levels, and Other Autoantibodies.- MGUS, Myeloma, Plasmacytoma.- IS the Risk of Multiple Myeloma Increased in Patients with Silicone Implants?.- Multiple Myeloma in Women with Silicone Breast Implants. Serum Immunoglobulin and lnterleukin-6 Studies in Women at Risk. With 3 Figures.- Silicone Gel Implants and Monoclonal Gammopathies: Three Cases of Multiple Myeloma and the Prevalence of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance.- Monoclonal Gammopathy of Undetermined Significance.- The National Cancer Institute Silicone Implant/Multiple Myeloma Registry.- The Epidemiology of Monoclonal Gammopathy of Unknown Significance: A Review.- Plasmacytoma Development in Mice Injected with Silicone Gels. With 6 Figures.- Epidemiology.- The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-Analysis.- The Prevalence of Breast Implants Among Women in the United States.- Epidemiology of Autoimmune and Immunological Diseases in Association with Silicone Implants: Is There an Excess of Clinical Disease or Antibody Response in Population-based or Other “Controlled” Studies?.