Section 1 Chemistry.- 1. Development of LHRH antagonists.- 2. LHRH antagonists with low histamine releasing activity.- 3. Specificity of design to achieve antagonists of LHRH of increasing effectiveness in therapeutic activity.- 4. Biosynthesis of LHRH.- 5. Phylogenetic diversity of LHRH.- Section 2 Mechanisms of Action of Hypothalamic LHRH and Analogs.- 6. Molecular mechanism of LHRH action in the gonadotrope.- 7. Mediation of the preovulatory LH surge: LHRH pulsatility and opioid modulation.- Section 3 Extra-Hypothalamic LHRH-Like Materials.- 8. LHRH binding sites in human tissues.- 9. LHRH and “LHRH-like” factors in the male reproductive tract.- 10. Placental LHRH-like activity.- Section 4 Pharmacology of LHRH Antagonists.- 11. In vitro histamine release with LHRH analogs.- 12. Anaphylactoid properties of LHRH analogs.- 13. Reproductive physiology and general pharmacology of LHRH antagonists.- 14. Suppression of plasma gonadotropins, testosterone and sperm production in adult male monkeys by a potent inhibitory analog of LHRH.- 15. LHRH antagonists and female reproductive function.- Section 5 Basic Clinical Studies.- 16. LHRH antagonists in normal men.- 17. Clinical investigations of the contraceptive and therapeutic potential of nafarelin.- 18. LHRH agonists and antagonists: therapeutic possibilities for premenstrual syndrome.- 19. Early clinical studies with LHRH antagonists in women.- 20. Profertility uses of LHRH agonist analogues.- Section 6 Clinical Trials.- 21. Ovulation induction with pulsatile LHRH.- 22. Treatment of endometriosis by nasal administration of nafarelin.- 23. Effects of nafarelin in precocious puberty.- 24. Pharmacokinetics, metabolism and clinical studies with buserelin.- 25. Trials with leuprolide.- 26. Zoladex studies in prostatic and breast cancer.- 27. Intermittent LHRH agonist sequentially combined with a progestogen as antiovulatory contraception.- 28. LHRH agonists and male contraception.- Section 7 Gonadal Protective Prospects with LHRH Analogs.- 29. Interactions between an LHRH analogue and cancer chemotherapeutic agents at the testicular level in dogs.- 30. Is it possible to conserve the fertility of patients with Hodgkin’s disease treated with cytotoxic chemotherapy?.- Section 8 Diagnostic Applications.- 31. Predicting predisposition to osteoporosis: GnRH antagonist for acute estrogen deficiency.- Section 9 Applications in Animals.- 32. The use of LHRH analogs in aquaculture.- 33. Uses of LHRH and its analogs in cattle.- 34. Clinical uses of LHRH analogs in dogs.- Section 10 Formulation and Metabolism.- 35. Intra-nasal administration of LHRH and its analogs.- 36. The controlled delivery of polypeptides including LHRH analogs.- 37. Pharmacokinetics and metabolism of LHRH analogs.- Epilogue.
